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KMID : 0984720060380030164
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Infection and Chemotherapy
2006 Volume.38 No. 3 p.164 ~ p.168
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Two Cases of Candida inconspicua Infection in Neutropenic Patients with Acute Leukemia
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Woo Hyun-Young
Park Sun-Hee
Lee Dong-Gun
Jo Hyun-Sun
Min Chang- Ki
Kim Myung-Shin
Han Kyung-Ja
Shin Wan-Shik
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Abstract
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Non-albicans Candida species which are resistant to azole are emerging as important pathogens in patients with hematological malignancies who received antifungal prophylaxis. C. inconspicua is one of rare Candida spp. and resistant to fluconazole and deep infection due to C. inconspicua has not been reported in Korea so far. We reported here two cases of candidemia due to C. inconspicua in neutropenic patients with acute leukemia. C. inconspicua were presumed to be originated from gastrointestinal tract in both cases. The antifungal susceptibility test of C. inconspicua in case 1 showed resistance to fluconazole and itraconazole. Both cases were successfully treated by amphotericin B deoxycholate. Clinicians should keep in mind that non-albicans Candida species would be emerging pathogen in immunocompromised hosts and early recognition and appropriate use of antifungal agents is necessary.
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KEYWORD
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Candida inconspicua, Fungemia, Neutropenia
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